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Additional manual searching was done in reference lists of included articles and in relevant peer-reviewed journals on either respiratory disease research or tobacco research

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Though some preclinical studies showed inhalation of PG and glycerol can be safe up to 28 days (Werley et al., 2011) or 18 months (Robertson et al., 1947), breathing aerosolized PG can also affect the risk of asthma development (Choi et al., 2010)

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